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The Los Santos Police Department is established.France gives the US the Statue of Happiness to celebrate the 100th anniversary of the country's independence.The first train for the Liberty City Subway is built.Satriale's Pork Store was built as a small storefront on Moog Street in Acter, Alderney.The first subway tunnel is built in Liberty City, however, it remains unused for 5 years until the first train was installed.The Hinterland clothing company was established.The Exchange collapses, causing economic problems for Liberty City.The Vangelico jewelry store is founded in Rockford Hills, Los Santos.The Hawk and Little firearm manufacturer is founded.Liberty Tree published its first newspaper exposing dishonest politicians only to be criticized by the public for instituting political bias.Blaine County is incorporated into the state of San Andreas.Marie Antoinette is beheaded by a guillotine on October 16.Portola Drive is established in Los Santos, San Andreas.Presumably, Cardiaque is founded by Maurice Cardiaque.The Alderney Museum is opened to the public in Alderney City, Alderney.August 27th: British warships enter the New Rotterdam harbor, renaming the area Liberty City.The East India Trading Company hired a cross-dressing director general for New Rotterdam named Gloria Hole (based on Peter Stuyvesant) to return civility and productivity to the colony.The first slave ships arrive in New Rotterdam.September 4th: English explorer Horatio Humboldt establishes the colony of New Rotterdam.Grand Theft Auto: Episodes from Liberty City The following Grand Theft Auto titles are set in the HD Universe:
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Note that the article does not include events from the 2D Universe and 3D Universe games, as they are officially confirmed not to take place in the same canon. The following is a timeline of events in the canon of the HD Universe of the Grand Theft Auto series, in the order in which they occurred. This cysteine oxidation-dependent pathway not only stimulates the TRPC6 channel by itself but also sensitizes the channels to diacylglycerol and promotes TRPC6 trafficking to the cell surface.Spoiler Warning: Plot details, ending details, or both are in the text which follows. These data indicate that H 2O 2 activates TRPC6 channels via modification of thiol groups of intracellular proteins. AVP also increased the fluorescence intensity on the surface of the cells co-transfected with TRPC6-EGFP and V1 receptor, and this response was inhibited by catalase. Similarly, in cells transfected with TRPC6-EGFP, confocal microscopy showed a significant increase in fluorescence intensity in the region of the cell membrane and adjacent to the membrane. Biotinylation assays revealed a significant increase in cell surface TRPC6 in response to H 2O 2. Moreover, 1-oleoyl-2-acetyl- sn-glycerol effect on TRPC6 was significantly greater in the presence of H 2O 2. Furthermore, both N-ethylmaleimide- and H 2O 2-induced TRPC6 activations were only observed in the cell-attached patches but not in the inside-out patches. Dithiothreitol or glutathione-reduced ethyl ester significantly antagonized the response. N-Ethylmaleimide and thimerosal were able to simulate the H 2O 2 response. Catalase substantially attenuated arginine vasopressin (AVP)-induced Ca 2+ entry in cells co-transfected with TRPC6 and AVP V1 receptor. H 2O 2 also evoked a robust inward current in A7r5 vascular smooth muscle cells, which was nearly abolished by knockdown of TRPC6 using a small interfering RNA. Electrophysiological experiments showed that H 2O 2 significantly increased TRPC6 channel open probability and whole-cell currents. In TRPC6-expressing HEK293T cells, H 2O 2 significantly stimulated Ca 2+ entry in a dose-dependent manner. This study examined the effect of H 2O 2 on the TRPC6 channel and its underlying mechanisms using a TRPC6 heterologous expression system.